Assay development

Our bioscience experts work with you to develop robust, reproducible assays that will reliably deliver throughout the drug discovery process. The team has particular expertise in developing cell-based assays.

Testing efficacy

In early drug discovery bioassays not only reveal whether a compound acts on a biological target but also how effective it is and if it has any potentially off target effects. In turn, this can influence decisions about whether the candidate warrants further study.

The importance of bioassays in early drug discovery may be clear, yet what is less clear is how bioassays should be developed to ensure they are optimised for their specific purpose.

Assay design and development is a complex process, involving many considerations that can each determine the specificity, sensitivity, and reliability of a compound’s action on a target. As such, if you develop your own assays, what you produce can mean the difference between valid and invalid results that help or hinder your drug discovery research.

Designing for success

Assay design is a major factor underpinning the success of any drug discovery programme. A well-designed assay should be one in which every step in the protocol has been evaluated.

One analogy is that assays are like aeroplanes; if you need to travel 500, 5,000 or 50,000 miles, you want to fly in a well-designed aeroplane and get the same outcome every flight: you arrive safely!

Whether built from literature or already existing, our focus is always on ensuring the assay is fit for purpose.

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Wide ranging experience

Our bioscience leadership has decades of large pharma experience in drug discovery gained in companies including Hoffmann La Roche, Smith Kline Beecham, GlaxoWellcome, AstraZeneca, ICI and UCB.

The wider team has worked in pre-clinical discovery, designing and developing low, medium and high throughput assays in both cellular and non-cellular assay formats.

They have experience of a wide range of technologies designed to prosecute these activities in a scalable manner whilst bringing to bear technological developments that have the ability to probe ever further into the molecular interactions from which the drugs of the future may be identified.

A culture of approaching problems as a group results in time efficient and cost effective assay development.

 

Our success stories

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