The bioscience division of Charnwood Molecular undertook a project on the assay development of a Surface Plasmon Resonance (SPR) assay to enable kinetic and affinity measurements of well-known BRD4-targeting PROTAC molecules.
The data allows us to infer different mechanistic details of the PROTAC / BRD4 interactions. Click here for full details of the case study.
We saw how SPR can provide interesting and important characterisation of binding modes that might be assumed to be very similar.