Job overview:
The Role
To build and develop a new Computational Chemistry Department at Charnwood Molecular.
Candidate specification:
Duties and Responsibilities:
- To add value to Charnwood Molecular by building and developing the Computational Chemistry Department
- To lead, manage and undertake structure based design, docking and ligand optimisation
- To lead, manage and undertake fragment based design projects
- To lead, manage and undertake protein sequence analysis and homology modelling- including multiple sequence alignment and homology modelling experience across numerous protein classes, including GPCRs
- To demonstrate use of computational tools and techniques including virtual screening, structure-activity relationships, and chemoinformatics
- To show ability and willingness to recruit and supervise colleagues in the Computational Chemistry Department, mentoring and supporting team members as required
- To be efficient in virtual screening – using protein x-ray structures and a variety of a ligand based methods such as shape and fingerprint based technologies.
- To lead the development of platform technologies within the company
- To identify new business opportunities and write proposals
- To take a proactive approach to one’s professional development
- To travel to, or work temporarily at, other Charnwood Molecular facilities in the UK from time to time as required
- To attend to any other incidental and general duties as specified from time to time by his/her Line Managers
- To use analytical skills and industry knowledge and experience to support Computational Chemistry Department
- To regularly and proactively update his/her Line Manager on the progress of work activities and associated projects
- To work with due consideration to the health and safety of oneself and one’s colleagues at all times.
Qualifications, Knowledge and Experience:
- A PhD in computational chemistry or a related discipline.
- Proven experience in structure based design – docking and ligand optimisation.
- Experience of working on fragment based design projects would also be an advantage.
- Several years’ experience working on small molecule drug discovery projects
- Experience of protein sequence analysis and homology modelling – experience of multiple sequence alignment and homology modelling experience across numerous protein classes, including GPCRs, would be an advantage.
- Experience of Ligand based design – SAR analysis of project data sets and calculation of ADME/Tox relevant properties including core replacement work and focussed library design.
- Experience with a variety of computational tools and techniques including virtual screening, structure-activity relationships, and chemoinformatics
- A drug discovery background gained within a pharmaceutical company or at a CRO is preferred.
Skills, Abilities and Competencies:
- Excellent communications & team working skills
- The skill set to recruit, train and support new and junior Computational Chemists.
- The ability to conduct virtual screening – using protein x-ray structures and a variety of a ligand based methods such as shape and fingerprint based technologies.
- The ability to lead the development of platform technologies within the company.
- The ability to identify new business opportunities and write proposals.
You are applying for the role of:
Computational Chemist
Job Role:
Computational Chemist
Location:
Nottingham
Duration:
Permanent
Start Date:
tbc
Salary:
Dependent on experience