Job Role:
Computational Chemist

Location:
Nottingham

Duration:
Permanent

Start Date:
tbc

Salary:
Dependent on experience

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Job overview:

The Role

To build and develop a new Computational Chemistry Department at Charnwood Molecular.

Candidate specification:

Duties and Responsibilities:

  • To add value to Charnwood Molecular by building and developing the Computational Chemistry Department
  • To lead, manage and undertake structure based design, docking and ligand optimisation
  • To lead, manage and undertake fragment based design projects
  • To lead, manage and undertake protein sequence analysis and homology modelling- including multiple sequence alignment and homology modelling experience across numerous protein classes, including GPCRs
  • To demonstrate use of computational tools and techniques including virtual screening, structure-activity relationships, and chemoinformatics
  • To show ability and willingness to recruit and supervise colleagues in the Computational Chemistry Department, mentoring and supporting team members as required
  • To be efficient in virtual screening – using protein x-ray structures and a variety of a ligand based methods such as shape and fingerprint based technologies.
  • To lead the development of platform technologies within the company
  • To identify new business opportunities and write proposals
  • To take a proactive approach to one’s professional development
  • To travel to, or work temporarily at, other Charnwood Molecular facilities in the UK from time to time as required
  • To attend to any other incidental and general duties as specified from time to time by his/her Line Managers
  • To use analytical skills and industry knowledge and experience to support Computational Chemistry Department
  • To regularly and proactively update his/her Line Manager on the progress of work activities and associated projects
  • To work with due consideration to the health and safety of oneself and one’s colleagues at all times.

Qualifications, Knowledge and Experience:

  • A PhD in computational chemistry or a related discipline.
  • Proven experience in structure based design – docking and ligand optimisation.
  • Experience of working on fragment based design projects would also be an advantage.
  • Several years’ experience working on small molecule drug discovery projects
  • Experience of protein sequence analysis and homology modelling – experience of multiple sequence alignment and homology modelling experience across numerous protein classes, including GPCRs, would be an advantage.
  • Experience of Ligand based design – SAR analysis of project data sets and calculation of ADME/Tox relevant properties including core replacement work and focussed library design.
  • Experience with a variety of computational tools and techniques including virtual screening, structure-activity relationships, and chemoinformatics
  • A drug discovery background gained within a pharmaceutical company or at a CRO is preferred.

Skills, Abilities and Competencies:

  • Excellent communications & team working skills
  • The skill set to recruit, train and support new and junior Computational Chemists.
  • The ability to conduct virtual screening – using protein x-ray structures and a variety of a ligand based methods such as shape and fingerprint based technologies.
  • The ability to lead the development of platform technologies within the company.
  • The ability to identify new business opportunities and write proposals.
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You are applying for the role of:

Computational Chemist

Job Role:
Computational Chemist

Location:
Nottingham

Duration:
Permanent

Start Date:
tbc

Salary:
Dependent on experience

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