Journal Publications

Work involving Charnwood Molecular’s chemistry team has seen regular publication in the peer-reviewed scientific and patent literature:

Synthesis and Activity of a Novel Autotaxin Inhibitor-Icodextrin Conjugate – N. Fisher, M.G. Edwards, R. Hemming, S.M. Allin, J.D. Wallis, P.C. B. Page, M.J. McKenzie, S. Jones, M.R.J. Elsegood, J. King-Underwood, and A. Richardson; J. Med. Chem., 2018, 61, 7942.

Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity – P. Johansson, K. Kaspersson, I.K. Gurrell, E. Back, S. Eketja, Clay W. Scott, G. Cebers, P. Thorne, M. J. McKenzie, H. Beaton, P. Davey, K. Kolmodin, J. Holenz, M.E. Duggan, S. Budd Haeberlein, and R.W. Burli, J. Med. Chem. 2018, 61, 3491.

New 4-Aryl-1,3,2-oxathiazolylium-5-olates: Chemical Synthesis and Photochemical Stability of a Novel Series of S-Nitrosothiols – M.E. Richardson, S.M. Allin, R.J. Pearson, Bioorg. Med. Chem. Lett., 2018, 28, 1106.

Formal Total Synthesis of (+)-C9-Deoxyomuralide from L-Leucine Using a Double Sacrificial Chirality Transfer Approach – P.C.B Page, R.L. Goodyear, A.E. Horton, Y. Chan, R. Karim, M.A. O’Connell, C. Hamilton, A.M.Z. Slawin, B.R. Buckley, S.M. Allin, J. Org. Chem. 2017, 82, 12209.

New Biphenyl Iminium Salt Catalysts for Highly Enantioselective
Asymmetric Epoxidation: Role of Additional Substitution and Dihedral
Angle – P.C.B. Page, C.J. Bartlett, Y. Chan, G.A. Jones, S.M. Allin, M.J. McKenzie, J. Lacour, R. Novikov, Organic & Biomolecular Chemistry, 2016, 14, 4220 – 4232!divAbstract

A Dendrimer Conjugate of 4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor – N. Fisher, T. Hilton-Bolt, M.G. Edwards, K. Haxton, M.J. McKenzie, S.M. Allin and A. Richardson, ACS Med. Chem. Lett, 2014, 5, 34.

Kinetic Resolution in Asymmetric Epoxidation using Iminium Salt Catalysis –
P.C.B. Page, L. Appleby, Y. Chan, D. Day, B. Buckley, A.M.Z. Slawin, S.M. Allin, M.J. McKenzie, J. Org. Chem, 2013, 78, 8074.

Enantioselective Total Synthesis of (+)-Scuteflorin A Using Organocatalytic Asymmetric Epoxidation – C.J. Bartlett, Y. Chan, D. Day, S.M. Allin, M.J. Mckenzie, A.M.Z. Slawin and P.C.B. Page, J. Org. Chem, 2012, 77, 772.

Enolate Amination and Derivatization of a Pyrroloisoquinoline Template: Towards Novel Peptidomimetics – S.M Allin, S.N Gaskell, J.M.R. Towler, P.C.B Page, Tetrahedron, 2010, 66, 9538.

Facile Asymmetric Construction of a Functionalized Dodecahydrobenz[a]indolo[3,2-h]quinolizine: Towards the Manadomanzamine Alkaloids – S.M. Allin, L.J. Duffy, J.M.R. Towler, P.C.B. Page, M.R.J. Elsegood and B. Saha, Tetrahedron, 2009, 65, 10230.

Highly Enantioselective Total Synthesis of (-)-(3’S)-Lomatin and (+)-(3’S, 4’R)-trans-Khellactone – P.C,B. Page, L.F. Appleby, D. Day, Y. Chan, B.R. Buckley, S.M. Allin and M.J. Mckenzie, Org. Lett, 2009, 11, 1991.

A New Asymmetric Synthesis of the Anti-tumour Alkaloid Crispine A – S.M. Allin, S.N. Gaskell, J.M.R. Towler, P.C.B. Page, B. Saha, M.J. Mckenzie and W.P. Martin, J. Org. Chem., 2007, 72, 8972.

In Situ Generation of o-Iodoxybenzoic Acid (IBX) in the Presence of Tetraphenylphosphonium Monoperoxysulfate (TPPP) for the Conversion of Primary Alcohols into the Corresponding Aldehydes – P.C.B. Page, L. Appleby and S.M. Allin, Synlett, 2007, 1565.

Novel Polymer-bound Aminoalcohol Ligands for the Asymmetric Addition of Diethylzinc to Aldehydes – P.C.B. Page, S.M. Allin, S.J. Maddocks and B.R. Buckley, Synth. Commun., 2007, 37, 2019.

Towards a Total Synthesis of the Manadomanzamine Alkaloids: The First Asymmetric Construction of the Pentacyclic Indole Core – S.M. Allin, L.J. Duffy, M.R.J. Elsegood, and P.C.B. Page, Tetrahedron Lett., 2007, 48, 4711.

A Short Preparation of an Advanced Intermediate for Lactacystin Synthesis: The Complete Carbon Skeleton of Clasto-Lactacystin Dihydroxyacid – P.C.B. Page, D.C. Leach, C.M. Hayman, A. Sazali Hamzah, S.M. Allin, V. McKee, Synlett, 2003, 1025.

A Short and Versatile Route to a Key Intermediate for Lactacystin Synthesis – P.C.B. Page, A. Sazali Hamzah, D.C. Leach, S.M. Allin, D.M. Andrews, G. A. Rassias, Org. Letts, 2003, 5, 353.

New Ligands for Asymmetric Diethylzinc Additions to Aromatic Aldehydes, Demonstrating Substrate-Dependent Non-linear Effects – P.C.B. Page, S.M. Allin and S.J. Maddocks, Perkin Trans 1, 2002, 2827.!divAbstract