Process Research and Development.

Our Process Research & Development team here at Charnwood Molecular has over 100 years of combined large pharma experience. The team strives for and maintains excellence in pre-clinical Process Chemistry R&D, enabling a smoother transition between Medicinal Chemistry and Chemical Development for our clients.

Process Research & Development.

Rather uniquely for a CRO, Charnwood Molecular has a select and committed team working at the interface of Medicinal Chemistry and Chemical Development.

At the outset of our Discovery projects, we encourage our clients to think ahead to the unique demands and challenges of Chemical Development. It is vital to ensure that pre-clinical supply can be forthcoming at the appropriate stage, and to speed up and reduce the costs of an eventual clinical supply (see Chemistry World, September 2016, 35).

Our Process Research & Development team here at Charnwood Molecular has over 100 years of combined large pharma experience. The team strives for and maintains excellence in pre-clinical Process Chemistry R&D, enabling a smoother transition between Medicinal Chemistry and Chemical Development for our clients. 

This is partly achieved through the provision of focused early Development support programs, which deliver: 

  • Pre-clinical non-GMP supply 
  • Process Chemistry R&D to access efficient chemistry (high yields, robust, fast throughput)
  • Enhanced of out-licensing offerings (including methods & samples)
  • Increased value and de-risked projects, with API supply ensured
  • Excellent technology transfer to cGMP scale-up

Bridging

Pragmatic adaptation of Discovery Chemistry to feed the early stage R&D engine with advanced intermediates; bridging new and improved methods to furnish the first larger batches of time critical development materials.

Novelty

Imaginative and bold Process Research ensures efficient and novel routes with attractive Intellectual Property prospects.

Quality

Expert analytical and process expertise is used to develop processes where throughput and yield are optimized, and side-products are identified and minimized.

Delivery

We will provide high quality finished batches of a development material along with a comprehensive account enabling seamless technical transfer.

Problem-Solving.

Given that most development activities are dependent on an adequate supply of API, it’s important to keep Chemical Development activities a phase ahead of the requirements of other departments. 

Although initial quantities of the API provide the fuel for the Development engine, ultimately, it’s the quality of the manufacturing process that is the most valuable output from the PR&D effort. Chemistry problems are solved more efficiently and economically in the laboratory rather than on plants, where costs increase 15-fold. Effective process research & development can therefore be hugely economical, saving time and costs in New Product Development.

Inefficient chemistry can typically cost a project up to 18 months in lost time, which negatively impacts New Product Value (NPV) by up to 30%. The 20-50kg campaign is often the real rate-limiting delivery stage, with a major impact on NPV. This needs to be considered early on in the process – a cornerstone of Charnwood Molecular’s PR&D group work with our clients. Here at Charnwood Molecular, your efficiency is our priority.  

Charnwood Molecular team member using lab equipment

Our state of the art equipment.

In order to continue providing our clients and partners with our world-class support, our PR&D group here at Charnwood Molecular has on-site access to a range of state-of-art equipment, including:

• Radleys Lara reactor systems (for control key reaction scale-up parameters)
• Mettler Toledo DSC3 (for safety and stability testing)
• Mettler Toledo Karl-Fischer V10S system (for water content determinations of intermediates and final products)
• Technobis Crystal 16 benchtop crystallisation system (for crystallisation screens – salt forms/polymorphs – and solubility determinations)
• Teledyne Isco Torrent chromatography system – Large scale chromatography with columns up to 3Kg.

Our Chemical Development Expertise.

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Our success stories.

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Medicinal Chemistry

Medicinal Chemistry Lead Optimisation (LO) 1

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Medicinal Chemistry

Medicinal Chemistry: Hit-to-Lead (H2L)

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More services.

Charnwood Molecular offers a range of additional services, including Process Research & Development, Medicinal Services and Grant Funding Partnerships. Find out more about our services.

Custom Synthesis

Our talented synthetic chemists have been delivering challenging molecular research for de

Custom Synthesis

Medicinal Chemistry

We have been providing expert medicinal chemistry support for decades.

Medicinal Chemistry

Grant Funding Partnerships

We have always had a unique understanding of the nature of grant-funded partnerships.

Grant Funding Partnerships

Contract Research including Route Development and Route Optimisation

For your contract research needs, get in touch with Charnwood Molecular today.

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